Au-Nanomaterials as a Superior Choice for Near-Infrared Photothermal Therapy

被引：105

作者：

Jabeen, Fahmida ^{[1
,2
]}

Najam-ul-Haq, Muhammad ^{[1
,2
]}

Javeed, Rabia ^{[1
]}

Huck, Christian W. ^{[2
]}

Bonn, Guenther K. ^{[2
]}

机构：

[1] Bahauddin Zakariya Univ, Inst Chem Sci, Div Analyt Chem, Multan 60800, Pakistan

[2] Leopold Franzens Univ, Inst Analyt Chem & Radiochem, A-6020 Innsbruck, Austria

来源：

MOLECULES | 2014年 / 19卷 / 12期

关键词：

near-infrared spectroscopy; nanoparticles/materials; therapy monitoring; GOLD NANOPARTICLES; CELLULAR UPTAKE; CANCER-CELLS; NANORODS; NANOSHELLS; NANOCAGES; TOXICITY; AGENTS; CHEMOTHERAPY; EFFICIENT;

D O I：

10.3390/molecules191220580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Photothermal therapy (PPT) is a platform to fight cancer by using multiplexed interactive plasmonic nanomaterials as probes in combination with the excellent therapeutic performance of near-infrared (NIR) light. With recent rapid developments in optics and nanotechnology, plasmonic materials have potential in cancer diagnosis and treatment, but there are some concerns regarding their clinical use. The primary concerns include the design of plasmonic nanomaterials which are taken up by the tissues, perform their function and then clear out from the body. Gold nanoparticles (Au NPs) can be developed in different morphologies and functionalized to assist the photothermal therapy in a way that they have clinical value. This review outlines the diverse Au morphologies, their distinctive characteristics, concerns and limitations to provide an idea of the requirements in the field of NIR-based therapeutics.

引用

页码：20580 / 20593

页数：14

共 61 条

[1]

Alcantar NA, 2000, J BIOMED MATER RES, V51, P343, DOI 10.1002/1097-4636(20000905)51:3<343::AID-JBM7>3.0.CO

[2]

2-D

[3]

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? [J].