Tracking of Multimodal Therapeutic Nanocomplexes Targeting Breast Cancer in Vivo

被引：129

作者：

Bardhan, Rizia ^{[2
]}

Chen, Wenxue ^{[1
,3
]}

Bartels, Marc ^{[1
]}

Perez-Torres, Carlos ^{[4
]}

Botero, Maria F. ^{[5
]}

McAninch, Robin Ward ^{[5
]}

Contreras, Alejandro ^{[5
]}

Schiff, Rachel ^{[5
]}

Pautler, Robia G. ^{[4
]}

Halas, Naomi J. ^{[2
,6
]}

Joshi, Amit ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA

[2] Rice Univ, Dept Chem, Houston, TX 77005 USA

[3] Hebei Med Univ, Hosp 4, Dept Obstet & Gynecol, Hebei Prov Tumor Hosp, Shijiazhuang 050011, Hebei Province, Peoples R China

[4] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[5] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA

[6] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 12期

关键词：

Multimodal imaging in vivo; nanoshells; fluorescence optical imaging; magnetic resonance imaging biodistribution; GOLD NANOPARTICLES; FLUORESCENCE ENHANCEMENT; STREPTAVIDIN; NANOSHELLS; BIODISTRIBUTION; CLEARANCE; PARTICLES; ABLATION; DELIVERY; PLATFORM;

D O I：

10.1021/nl102889y

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Nanoparticle based therapeutics with local delivery and external electromagnetic field modulation holds extraordinary promise for soft tissue cancers such as breast cancer however knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical translation Here we demonstrate that multiple diagnostic capabilities can be Introduced in photothermal therapeutic nanocomplexes by simultaneously enhancing both near Infrared fluorescence and magnetic resonance imaging (MRI) We track nanocomplexes in vivo, examining the influence of HER2 antibody targeting on nanocomplex distribution over 72 h This approach provides valuable detailed information regarding the distribution and Fate of complex nanoparticles designed for specific diagnostic and therapeutic functions

引用

页码：4920 / 4928

页数：9

共 52 条

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Nanocrystal targeting in vivo [J].