Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

被引：181

作者：

Bardhan, Rizia ^{[1
]}

Chen, Wenxue ^{[2
]}

Perez-Torres, Carlos ^{[5
]}

Bartels, Marc ^{[2
]}

Huschka, Ryan M. ^{[1
]}

Zhao, Liang L. ^{[6
]}

Morosan, Emilia ^{[6
]}

Pautler, Robia G. ^{[5
]}

Joshi, Amit ^{[2
]}

Halas, Naomi J. ^{[1
,3
,4
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77005 USA

[2] Baylor Coll Med, Dept Radiol, Houston, TX 77005 USA

[3] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA

[4] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[5] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77005 USA

[6] Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2009年 / 19卷 / 24期

关键词：

IRON-OXIDE NANOPARTICLES; FLUORESCENCE ENHANCEMENT; TUMORS; MRI; RELAXATION; EXPRESSION; GROWTH; FE3O4; CORE;

D O I：

10.1002/adfm.200901235

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Integrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously-fluorescence optical imaging and magnetic resonance imaging-with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell-based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe3O4 and the fluorophore ICG, which results in a high T-2 relaxivity (390 mM(-1) s(-1)) and 45X fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near-IR illumination.

引用

页码：3901 / 3909

页数：9

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