Subchondral Cystlike Lesions Develop Longitudinally in Areas of Bone Marrow Edema-like Lesions in Patients with or at Risk for Knee Osteoarthritis: Detection with MR Imaging-The MOST Study

被引：95

作者：

Crema, Michel D. ^{[1
,3
]}

Roemer, Frank W. ^{[1
,4
]}

Zhu, Yanyan ^{[2
]}

Marra, Monica D. ^{[1
,3
]}

Niu, Jingbo ^{[2
]}

Zhang, Yuqing ^{[2
]}

Lynch, John A. ^{[5
]}

Javaid, M. Kassim ^{[5
]}

Lewis, Cora E. ^{[6
]}

El-Khoury, George Y. ^{[7
]}

Felson, David T. ^{[2
]}

Guermazi, Ali ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

[3] Univ Sao Paulo, Div Radiol, Dept Internal Med, Sao Paulo, Brazil

[4] Klinikum Augsburg, Dept Radiol, Augsburg, Germany

[5] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[6] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA

[7] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA

来源：

RADIOLOGY | 2010年 / 256卷 / 03期

关键词：

ARTICULAR-CARTILAGE; HIP; PATTERN; ACCURACY; DEFECTS; SIGNAL; JOINT;

D O I：

10.1148/radiol.10091467

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To assess the association of prevalent bone marrow edema-like lesions (BMLs) and full-thickness cartilage loss with incident subchondral cyst-like lesions (SCs) in the knee to evaluate the bone contusion versus synovial fluid intrusion theories of SC formation. Materials and Methods: The Multicenter Osteoarthritis study is a longitudinal study of individuals who have or are at risk for knee osteoarthritis. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all participants. Magnetic resonance images were acquired at baseline and 30-month follow-up and read semiquantitatively by using the Whole-Organ Magnetic Resonance Imaging Score system. The tibiofemoral and patellofemoral joints were subdivided into 14 subregions. BMLs and SCs were scored from 0 to 3. Cartilage morphology was scored from 0 to 6. The association of prevalent BMLs and full-thickness cartilage loss with incident SCs in the same subregion was assessed by using logistic regression with mutual adjustment for both predictors. Results: A total of 1283 knees were included. After adjustment for full-thickness cartilage loss, prevalent BMLs showed a strong and significant association with incident SCs in the same subregion, with an odds ratio of 12.9 (95% confidence interval [CI]: 8.9, 18.6). After adjustment for BMLs, prevalent full-thickness cartilage loss showed a significant but much less important association with incident SCs in the same subregion (odds ratio, 1.4; 95% CI: 1.0, 2.0). There was no apparent relationship between severity of full-thickness cartilage loss at baseline and incident SCs. Conclusion: Prevalent BMLs strongly predict incident SCs in the same subregion, even after adjustment for full-thickness cartilage loss, which supports the bone contusion theory of SC formation. (C) RSNA, 2010

引用

页码：855 / 862

页数：8

共 24 条

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