Palladium-catalyzed asymmetric allylic alkylation with an enamine as the nucleophilic reagent

被引：66

作者：

Liu, Delong ^{[1
]}

Xie, Fang ^{[1
]}

Zhang, Wanbin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai, Peoples R China

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 43期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetlet.2007.08.119

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enamine can serve as a good nucleophile for palladium-catalyzed asymmetric allylic alkylation, avoiding the use of an unstablilized ketone enolate formed by strong bases. In the presence of a palladium complex of chiral metallocene-based phosphino-oxazoline ligands, the reaction was carried out smoothly with high catalytic activity and excellent enantioselectivity. Different distances between the two Cp rings of ferrocene and ruthenocene affected the catalytic behavior in the reaction. Furthermore, high catalytic activity and good enantio selectivity were also afforded by the ferrocene-based diphosphine ligands with only planar chirality. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7591 / 7594

页数：4

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