First total synthesis of macrosphelides C and F

被引：28

作者：

Kobayashi, Y ^{[1
]}

Acharya, HP ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

关键词：

asymmetric synthesis; furans; macrolides; macrosphelide C; macrosphelide F;

D O I：

10.1016/S0040-4039(01)00285-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrosphelides C and F were synthesized by lactonization of 14-oxo seco acids at the O(10)-C(11) bond followed by reduction and Mitsunobu inversion of the resulting hydroxyl group. The seco acids were prepared from the corresponding furans by furan ring-opening with NBS followed by further oxidation of the 4-oxo-2-alkenals with NaClO2. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2817 / 2820

页数：4

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