The Salmonella translocated effector SopA is targeted to the mitochondria of infected cells

被引：30

作者：

Layton, AN ^{[1
]}

Brown, PJ ^{[1
]}

Galyov, EE ^{[1
]}

机构：

[1] Inst Anim Hlth, Div Microbiol, Compton RG20 7NN, Berks, England

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1128/JB.187.10.3565-3571.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study investigates the Salmonella effector protein SopA. We show that in Salmonella enterica serovar Dublin-infected cells, SopA(1-347) fused to two carboxy-terminal hemagglutinin tags partially colocalized with mitochondria. Transfection of eukaryotic cells with a panel of constructs encoding truncated versions of SopA identified that amino acids 100 to 347 were sufficient to target SopA to the mitochondria.

引用

页码：3565 / 3571

页数：7

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