Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese

被引：40

作者：

Yang, JD

Feng, GY

Zhang, J

Lin, ZX

Shen, T

Breen, G

St Clair, D

He, L ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Bio X Live Sci Res Ctr, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China

[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[4] Univ Aberdeen, Sch Med, Dept Mental Hlth, Aberdeen AB25 2ZD, Scotland

来源：

NEUROSCIENCE LETTERS | 2000年 / 295卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

angiotensin-converting enzyme; Alzheimer's disease; apolipoprotein;

D O I：

10.1016/S0304-3940(00)01591-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is now overwhelming evidence that the epsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (IID) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR) = 2.09, P = 0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P < 0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. (C) 2000 Published by Elsevier Science ireland Ltd.

引用

页码：41 / 44

页数：4

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