Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment:: relationship with cognitive performance

被引:35
作者
Bartrés-Faz, D
Junqué, C
Clemente, IC
López-Alomar, A
Valveny, N
López-Guillén, A
López, T
Cubells, MJ
Moral, P
机构
[1] Univ Barcelona, Dept Psychiat & Psychobiol, Psychobiol Unit, Barcelona 08035, Catalunya, Spain
[2] Univ Barcelona, Dept Biol Anim, Anthropol Unit, Barcelona 08035, Catalunya, Spain
[3] CAP Rambla, Barcelona, Catalunya, Spain
[4] CAP Lepanto, Barcelona, Catalunya, Spain
关键词
age-associated memory impairment; ACE; elder; memory; neuropsychology; polymorphism;
D O I
10.1016/S0304-3940(00)01349-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We compared the distribution of an insertion (I)/deletion (D) polymorphism coding for the angiotensin I converting enzyme (ACE) gene in 100 subjects fulfilling NIMH criteria for Age-associated memory impairment (AAMI) and 124 controls. We found significantly reduced prevalences of the ACE I/I genotype together with increases of the ACE D allele in the AAMI group. We further compared the neuropsychological performance of the AAMI group according to their ACE genotype. Those AAMI subjects presenting the ACE I/I genotype exhibited better performance on a measure of frontal robe function. Our results suggest that the lack of the ACE I/I genotype and the presence of the ACE D allele are associated with memory impairment in the elderly. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:177 / 180
页数:4
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