Predictive value of gross classification of hepatocellular carcinoma on recurrence and survival after hepatectomy

被引:115
作者
Hui, AM
Takayama, T
Sano, K
Kubota, K
Akahane, M
Ohtomo, K
Makuuchi, M
机构
[1] Univ Tokyo, Grad Sch Med, Dept Surg, Div Hepato Biliary Pancreat Surg,Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Radiol, Bunkyo Ku, Tokyo 1130033, Japan
关键词
gross classification; hepatocellular carcinoma; recurrence; survival;
D O I
10.1016/S0168-8278(00)80131-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aim: A new gross classification of hepatocellular carcinoma in which Eggel's nodular type is subclassified into type 1 (single nodular type), type 2 (single nodular type with extranodular growth), and type 3 (contiguous multinodular type) has been widely used in Japan. The aim of the study was to determine whether this classification is correlated with patient outcome. Methods: Sixty-five resected hepatocellular carcinoma nodules (less than or equal to5 cm) were classified using this new classification. Results: The 65 tumors were classified into 30 type 1 (46%), 20 type 2 (31%), and 15 type 3 (23%) hepatocellular carcinomas. The rate of microscopic vascular invasion significantly increased from type 1 to type 2, and to type 3 tumors (p=0.03), Kaplan-Meier estimates showed that type 1 was significantly associated with lower recurrence rate (type 1 vs type 2, p=0.01; type 1 vs. type 3, p=0.004; log-rank test), and higher disease-specific survival (type 1 vs. type 2, p=0.02; type 1 vs. type 3, p=0.002), Cox's proportional-hazards model demonstrated that type 1 was an independent factor for low risk of recurrence (p=0.002) and low risk of disease-specific death (p=0.02), Conclusion: The gross classification of hepatocellular carcinoma is of clinical value in predicting patient outcome.
引用
收藏
页码:975 / 979
页数:5
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