Cytotoxic activity of Origanum dictamnus

被引：36

作者：

Chinou, Ioanna ^{[1
]}

Liolios, Christos

Moreau, Dimitri

Roussakis, Christos

机构：

[1] Univ Athens, Sch Pharm, Div Pharmacog & Chem Nat Prod, Athens 15771, Greece

[2] ISOMer, Fac Pharm Nantes, Lab Pharmacol Marine, F-44322 Nantes 03, France

来源：

FITOTERAPIA | 2007年 / 78卷 / 05期

关键词：

Origanum dictamnus; cytotoxic activity; ursolic acid; murine leukemia;

D O I：

10.1016/j.fitote.2007.02.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several extracts of Origanum dictamnus, an endemic plant of Greece growing only in the island of Crete and the bioassay-directed isolated ursolic acid, were tested in vitro against the P388 (murine leukemia) and the human bronchial epidermoid cancer NSCLC-N6 (non small cell lung cancer) cell lines. Both the initial dichloromethane extract and the isolated from it ursolic acid exhibited cytotoxic activity. Ursolic acid was also tested in vivo, on murine ascite leukemia P388, where it exhibited at a dose of 50 mg/kg a marginal antileukemic activity. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：342 / 344

页数：3

共 12 条

[1]

CYTOTOXIC AND ANTIBACTERIAL LABDANE-TYPE DITERPENES FROM THE AERIAL PARTS OF CISTUS-INCANUS SUBSP CRETICUS [J].

CHINOU, I ;

DEMETZOS, C ;

HARVALA, C ;

ROUSSAKIS, C ;

VERBIST, JF .

PLANTA MEDICA, 1994, 60 (01) :34-36

[2]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[3]

HARVALA C, 1987, PLANTA MED, V1, P107

[4]

JUSTICIDIN-B, A CYTO-TOXIC PRINCIPLE FROM JUSTICIA-PECTORALIS [J].

JOSEPH, H ;

GLEYE, J ;

MOULIS, C ;

MENSAH, LJ ;

ROUSSAKIS, C ;

GRATAS, C .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (03) :599-600

[5]

LEE K, 1988, PLANTA MED, V4, P308

[6]

RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[7]

TRITERPENES FROM AMARACUS-DICTAMNUS [J].

PIOZZI, F ;

PATERNOSTRO, M ;

PASSANNANTI, S ;

GACSBAITZ, E .

PHYTOCHEMISTRY, 1986, 25 (02) :539-541

[8]

POLUNIN O, 1997, FLOWERS GREECE BALKA, P406

[9]

Skaltsa H., 1987, PLANT MED PHYTOTHER, V1, P56

[10]

SKALTSA H, 1986, PLANT MED PHYTOTHER, V4, P300

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