Inhibition of matrix metalloproteinase-9 by "multi-prong'' surface binding groups

被引：13

作者：

Banerjee, AL ^{[1
]}

Tobwala, S ^{[1
]}

Haldar, MK ^{[1
]}

Swanson, M ^{[1
]}

Roy, BC ^{[1
]}

Mallik, S ^{[1
]}

Srivastava, DK ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Chem Biochem & Mol Biol, Fargo, ND 58105 USA

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 20期

关键词：

D O I：

10.1039/b501780g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy of blocking the active site accessibility of MMP-9 by "multi-prong'' surface binding groups is described.

引用

页码：2549 / 2551

页数：3

共 19 条

[1]

ADAM SR, 2002, J AM CHEM SOC, V124, P6065

[2] Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase - II [J].

Banerjee, AL ;

Swanson, M ;

Roy, BC ;

Jia, X ;

Haldar, MK ;

Mallik, S ;

Srivastava, DK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (35) :10875-10883

[3] Cancer therapy - Matrix metalloproteinase inhibitors and cancer: Trials and tribulations [J].

Coussens, LM ;

Fingleton, B ;

Matrisian, LM .

SCIENCE, 2002, 295 (5564) :2387-2392

[4] Application and limitations of X-ray crystallographic data in structure-based ligand and drug design [J].

Davis, AM ;

Teague, SJ ;

Kleywegt, GJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (24) :2718-2736

[5] New functions for the matrix metalloproteinases in cancer progression [J].

Egeblad, M ;

Werb, Z .

NATURE REVIEWS CANCER, 2002, 2 (03) :161-174

[6] Tethering: Fragment-based drug discovery [J].

Erlanson, DA ;

Wells, JA ;

Braisted, AC .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2004, 33 :199-223

[7] Reversible "irreversible" inhibition of chymotrypsin using nanoparticle receptors [J].

Fischer, NO ;

Verma, A ;

Goodman, CM ;

Simard, JM ;

Rotello, VM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (44) :13387-13391

[8]

GEOGE KM, 2003, J BIOL CHEM, V278, P45512

[9] Genomics and proteomics tools for compound mode-of-action studies in drug discovery [J].

Kley, N ;

Ivanov, I ;

Meier-Ewert, S .

PHARMACOGENOMICS, 2004, 5 (04) :395-404

[10] PROTEIN FOLDING AND ASSOCIATION - INSIGHTS FROM THE INTERFACIAL AND THERMODYNAMIC PROPERTIES OF HYDROCARBONS [J].

NICHOLLS, A ;

SHARP, KA ;

HONIG, B .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1991, 11 (04) :281-296

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