Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules

被引：135

作者：

Kamphuis, Marloes M. J. ^{[1
]}

Johnston, Angus P. R. ^{[1
]}

Such, Georgina K. ^{[1
]}

Dam, Henk H. ^{[1
]}

Evans, Richard A. ^{[2
]}

Scott, Andrew M.

Nice, Edouard C.

Heath, Joan K.

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Ctr Nanosci & Nanotechnol, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia

[2] CSIRO Mol & Hlth Technol, Clayton, Vic 3168, Australia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 45期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

CHEMISTRY;

D O I：

10.1021/ja106405c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.

引用

页码：15881 / 15883

页数：3

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