Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

被引：65

作者：

Shi, Meng ^{[1
,2
,3
]}

Lu, Jiao ^{[3
,4
]}

Shoichet, Molly S. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Donnelly Ctr Cellular & Biomol Res 514, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Inst Biomat & Biomed Engn, Donnelly Ctr Cellular & Biomol Res 514, Toronto, ON M5S 3E1, Canada

[3] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Donnelly Ctr Cellular & Biomol Res 514, Toronto, ON M5S 3E1, Canada

[4] Univ Toronto, Dept Chem, Donnelly Ctr Cellular & Biomol Res 514, Toronto, ON M5S 3E1, Canada

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 31期

关键词：

DIELS-ALDER REACTIONS; STERICALLY STABILIZED LIPOSOMES; POLY(LACTIC ACID) NANOPARTICLES; BLOCK-COPOLYMER MICELLES; IN-VITRO; CLICK CHEMISTRY; MULTIDRUG-RESISTANCE; MONOCLONAL-ANTIBODY; CIRCULATION TIME; CELLULAR UPTAKE;

D O I：

10.1039/b822319j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanoscale carriers are of increasing interest for use in anticancer therapy because they can deliver drugs in a targeted way. Ideally, nanocarriers combine passive and active delivery mechanisms, by integrating targeting ligands on the surface of their stealth corona using simple and efficient conjugation chemistry. This feature article summarizes the conventional and newly explored conjugation chemistries that are used to bind ligands in organic nanoparticle systems, providing strategic guidance for the preparation of targeted nanocarriers.

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页码：5485 / 5498

页数：14

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