The Subcallosal Cingulate Gyrus in the Context of Major Depression

被引：364

作者：

Hamani, Clement ^{[1
,2
]}

Mayberg, Helen ^{[3
,4
]}

Stone, Scellig ^{[1
]}

Laxton, Adrian ^{[1
]}

Haber, Suzanne ^{[5
]}

Lozano, Andres M. ^{[1
]}

机构：

[1] Univ Toronto, Div Neurosurg, Univ Hlth Network, Toronto Western Hosp, Toronto, ON M5T 2S8, Canada

[2] Ctr Addict & Mental Hlth, Sect Neuroimaging, Toronto, ON, Canada

[3] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

[5] Univ Rochester, Dept Neurobiol & Anat, Rochester, NY USA

来源：

BIOLOGICAL PSYCHIATRY | 2011年 / 69卷 / 04期

关键词：

Brodmann area 25; cingulate gyrus; cingulum; corpus callosum; deep brain stimulation; depression; prefrontal cortex; psychiatry; DEEP BRAIN-STIMULATION; MEDIAL PREFRONTAL CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; LOCAL CIRCUIT NEURONS; CORTICAL PROJECTIONS; ANTERIOR CINGULATE; DIFFERENTIAL CONNECTIONS; THALAMIC PROJECTIONS; RHESUS-MONKEY; AREAS; 24A; B; C;

D O I：

10.1016/j.biopsych.2010.09.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The subcallosal cingulate gyrus (SCG), including Brodmann area 25 and parts of 24 and 32, is the portion of the cingulum that lies ventral to the corpus callosum. It constitutes an important node in a network that includes cortical structures, the limbic system, thalamus, hypothalamus, and brainstem nuclei. Imaging studies have shown abnormal SCG metabolic activity in patients with depression, a pattern that is reversed by various antidepressant therapies. The involvement of the SCG in mechanisms of depression and its emerging potential role as a surgical target for deep brain stimulation has focused recent interest in this area. We review anatomic and histologic attributes of the SCG and the morphologic and imaging changes observed in depression. Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region.

引用

页码：301 / 308

页数：8

共 102 条

[1]

Viewpoint -: How can drug discovery for psychiatric disorders be improved? [J].