学术探索
学术期刊
新闻热点
数据分析
智能评审

Naip5/Birc1e and susceptibility to Legionella pneumophila

被引：43
作者：
Fortier, A
Diez, E
Gros, P
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Ctr Study Host Resistance, Montreal, PQ H3G 1Y6, Canada
来源：
TRENDS IN MICROBIOLOGY | 2005年 / 13卷 / 07期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/j.tim.2005.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic analysis in mice is a powerful approach for the identification of genes and proteins that have a key role at the interface of the host-pathogen interaction. The Lgn1 locus has been found to control the intracellular replication of Legionella pneumophila in murine macrophages. Using functional complementation in transgenic mice, the Naip5/Birc1e gene has been identified as responsible for the Lgn1 effect. The classification of Naip5/Birc1e as a member of the NLR protein family suggests that Naip5/Birc1e acts as an intracellular sensor of L. pneumophila. The nature of the signal transduced by Naip5/Birc1e in response to Legionella products is of great interest but is currently unknown. Here, several possible scenarios are presented.
引用
收藏
页码：328 / 335
页数：8
相关论文
共 68 条
  • [11] Genetic and physical mapping of the mouse host resistance locus Lgn1
    Diez, E
    Beckers, MC
    Ernst, E
    DiDonato, CJ
    Simard, LR
    Morissette, C
    Gervais, F
    Yoshida, SI
    Gros, P
    [J]. MAMMALIAN GENOME, 1997, 8 (09) : 682 - 685
  • [12] The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
    Diez, E
    Yaraghi, Z
    MacKenzie, A
    Gros, P
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (03) : 1470 - 1477
  • [13] Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila
    Diez, E
    Lee, SH
    Gauthier, S
    Yaraghi, Z
    Tremblay, M
    Vidal, S
    Gros, P
    [J]. NATURE GENETICS, 2003, 33 (01) : 55 - 60
  • [14] Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2
    Erridge, C
    Pridmore, A
    Eley, A
    Stewart, J
    Poxton, IR
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 53 (08) : 735 - 740
  • [15] Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions
    Forbes, JR
    Gros, P
    [J]. TRENDS IN MICROBIOLOGY, 2001, 9 (08) : 397 - 403
  • [16] Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity
    Gao, LY
    Abu Kwaik, Y
    [J]. INFECTION AND IMMUNITY, 1999, 67 (02) : 862 - 870
  • [17] Activation of caspase 3 during Legionella pneumophila-induced apoptosis
    Gao, LY
    Abu Kwaik, Y
    [J]. INFECTION AND IMMUNITY, 1999, 67 (09) : 4886 - 4894
  • [18] Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2
    Girard, R
    Pedron, T
    Uematsu, S
    Balloy, V
    Chignard, M
    Akira, S
    Chaby, R
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (02) : 293 - 302
  • [19] CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
    Girardin, SE
    Tournebize, R
    Mavris, M
    Page, AL
    Li, XA
    Stark, GR
    Bertin, J
    DiSefano, PS
    Yaniv, M
    Sansonetti, PJ
    Philpott, DJ
    [J]. EMBO REPORTS, 2001, 2 (08) : 736 - 742
  • [20] Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan
    Girardin, SE
    Boneca, IG
    Carneiro, LAM
    Antignac, A
    Jéhanno, M
    Viala, J
    Tedin, K
    Taha, MK
    Labigne, A
    Zähringer, U
    Coyle, AJ
    Bertin, J
    Sansonetti, PJ
    Philpott, DJ
    [J]. SCIENCE, 2003, 300 (5625) : 1584 - 1587
1234567