Genes involved in senescence and immortalization

被引：248

作者：

Lundberg, AS

Hahn, WG

Gupta, P

Weinberg, RA

机构：

[1] Whitehead Inst, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(00)00155-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A) p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.

引用

收藏

页码：705 / 709

页数：5

相关论文

共 57 条

[31] Extension of cell life-span and telomere length in animals cloned from senescent somatic cells [J].

Lanza, RP ;

Cibelli, JB ;

Blackwell, C ;

Cristofalo, VJ ;

Francis, MK ;

Baerlocher, GM ;

Mak, J ;

Schertzer, M ;

Chavez, EA ;

Sawyer, N ;

Lansdorp, PM ;

West, MD .

SCIENCE, 2000, 288 (5466) :665-669

[32] Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species [J].

Lee, AC ;

Fenster, BE ;

Ito, H ;

Takeda, K ;

Bae, NS ;

Hirai, T ;

Yu, ZX ;

Ferrans, VJ ;

Howard, BH ;

Finkel, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (12) :7936-7940

[33] Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling [J].

Lin, AW ;

Barradas, M ;

Stone, JC ;

van Aelst, L ;

Serrano, M ;

Lowe, SW .

GENES & DEVELOPMENT, 1998, 12 (19) :3008-3019

[34] Cellular response to oncogenic Ras involves induction of the Cdk4 and Cdk6 inhibitor p15INK4b [J].

Malumbres, M ;

Perez de Castro, I ;

Hernández, MI ;

Jiménez, M ;

Corral, T ;

Pellicer, A .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (08) :2915-2925

[35] Accumulation of short telomeres in human fibroblasts prior to replicative senescence [J].

Martens, UM ;

Chavez, EA ;

Poon, SSS ;

Schmoor, C ;

Landsdorp, PM .

EXPERIMENTAL CELL RESEARCH, 2000, 256 (01) :291-299

[36] Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts [J].

McConnell, BB ;

Starborg, M ;

Brookes, S ;

Peters, G .

CURRENT BIOLOGY, 1998, 8 (06) :351-354

[37] The p66shc adaptor protein controls oxidative stress response and life span in mammals [J].

Migliaccio, E ;

Giorgio, M ;

Mele, S ;

Pelicci, G ;

Reboidl, P ;

Pandolfi, PP ;

Lanfrancone, L ;

Pelicci, PG .

NATURE, 1999, 402 (6759) :309-313

[38]

Munro J, 1999, CANCER RES, V59, P2516

[39] CLONING OF SENESCENT CELL-DERIVED INHIBITORS OF DNA-SYNTHESIS USING AN EXPRESSION SCREEN [J].

NODA, A ;

NING, Y ;

VENABLE, SF ;

PEREIRASMITH, OM ;

SMITH, JR .

EXPERIMENTAL CELL RESEARCH, 1994, 211 (01) :90-98

[40] THEORY OF MARGINOTOMY - INCOMPLETE COPYING OF TEMPLATE MARGIN IN ENZYMIC-SYNTHESIS OF POLYNUCLEOTIDES AND BIOLOGICAL SIGNIFICANCE OF PHENOMENON [J].

OLOVNIKOV, AM .

JOURNAL OF THEORETICAL BIOLOGY, 1973, 41 (01) :181-190

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