The role of taxanes in breast cancer treatment

被引：7

作者：

Levin, M ^{[1
]}

机构：

[1] SUNY Downstate Coll Med, Lincoln Med & Mental Hlth Ctr, Ctr Canc, Div Hematol & Oncol, Bronx, NY 10451 USA

来源：

DRUGS OF TODAY | 2001年 / 37卷 / 01期

关键词：

D O I：

10.1358/dot.2001.37.1.608782

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer of the breast is a serious public health problem throughout the world. Chemotherapy remains the mainstay of treatment of both early stage and metastatic breast cancer. New advances in chemotherapy include paclitaxel and docetaxel. This article reviews the historical background to the inrtroduction of these highly active agents, their biochemistry, mechanism of action and pharmacology, dose and schedule in the treatment of breast cancer, first- and second-line use as well as anthracycline/taxane combinations. Adjuvant, neoadjuvant use and the emergence of weekly taxanes is discussed. (C) 2001 Prous Science. All rights reserved.

引用

页码：57 / 65

页数：9

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