Sleep State Switching

被引：920

作者：

Saper, Clifford B. ^{[1
,2
,3
]}

Fuller, Patrick M. ^{[1
,2
,3
]}

Pedersen, Nigel P. ^{[1
,2
,3
]}

Lu, Jun ^{[1
,2
,3
]}

Scammell, Thomas E. ^{[1
,2
,3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Program Neurosci, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Div Sleep Med, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

NEURON | 2010年 / 68卷 / 06期

关键词：

VENTROLATERAL PREOPTIC NUCLEUS; THALAMIC RETICULAR NUCLEUS; EYE-MOVEMENT SLEEP; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; LOCUS-COERULEUS NEURONS; HISTAMINERGIC TUBEROMAMMILLARY NEURONS; FOREBRAIN CHOLINERGIC NEURONS; ENTRAINABLE CIRCADIAN-RHYTHMS; WAKING DISCHARGE PATTERNS; ASCENDING AROUSAL SYSTEM;

D O I：

10.1016/j.neuron.2010.11.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions. In this review, we examine the basic circuitry underlying the regulation of sleep and wakefulness and discuss a theoretical framework wherein the interactions between reciprocal neuronal circuits enable relatively rapid and complete state transitions. We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy.

引用

页码：1023 / 1042

页数：20

共 236 条

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