共 21 条
miRNAs get an early start on translational silencing
被引:184
作者:
Meister, Gunter
[1
]
机构:
[1] Max Planck Inst Biochem, Lab RNA Biol, Munich Ctr Integrated Prot Sci, CiPSM, D-82152 Martinsried, Germany
来源:
关键词:
D O I:
10.1016/j.cell.2007.09.021
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
MicroRNAs (miRNAs) control gene expression by regulating mRNA stability and translation. Using cell-free in vitro systems, several labs have recently reported insights into the molecular mechanisms underlying miRNA-guided translational repression (Kiriakidou et al., 2007; Mathonnet et al., 2007; Thermann and Hentze, 2007; Wakiyama et al., 2007). These new findings indicate that miRNAs inhibit translation at early steps of initiation.
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页码:25 / 28
页数:4
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