miRNAs get an early start on translational silencing

被引:184
作者
Meister, Gunter [1 ]
机构
[1] Max Planck Inst Biochem, Lab RNA Biol, Munich Ctr Integrated Prot Sci, CiPSM, D-82152 Martinsried, Germany
关键词
D O I
10.1016/j.cell.2007.09.021
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MicroRNAs (miRNAs) control gene expression by regulating mRNA stability and translation. Using cell-free in vitro systems, several labs have recently reported insights into the molecular mechanisms underlying miRNA-guided translational repression (Kiriakidou et al., 2007; Mathonnet et al., 2007; Thermann and Hentze, 2007; Wakiyama et al., 2007). These new findings indicate that miRNAs inhibit translation at early steps of initiation.
引用
收藏
页码:25 / 28
页数:4
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