miRNAs get an early start on translational silencing

被引：184

作者：

Meister, Gunter ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Lab RNA Biol, Munich Ctr Integrated Prot Sci, CiPSM, D-82152 Martinsried, Germany

来源：

CELL | 2007年 / 131卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.09.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) control gene expression by regulating mRNA stability and translation. Using cell-free in vitro systems, several labs have recently reported insights into the molecular mechanisms underlying miRNA-guided translational repression (Kiriakidou et al., 2007; Mathonnet et al., 2007; Thermann and Hentze, 2007; Wakiyama et al., 2007). These new findings indicate that miRNAs inhibit translation at early steps of initiation.

引用

页码：25 / 28

页数：4