Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy

被引：56

作者：

Westermeier, Francisco ^{[1
,2
]}

Navarro-Marquez, Mario ^{[1
,2
]}

Lopez-Crisosto, Camila ^{[1
,2
]}

Bravo-Sagua, Roberto ^{[1
,2
]}

Quiroga, Clara ^{[1
,2
]}

Bustamante, Mario ^{[1
,2
]}

Verdejo, Hugo E. ^{[3
]}

Zalaquett, Ricardo ^{[3
]}

Ibacache, Mauricio ^{[4
]}

Parra, Valentina ^{[1
,2
,5
,6
]}

Castro, Pablo F. ^{[3
]}

Rothermel, Beverly A. ^{[5
,6
]}

Hill, Joseph A. ^{[5
,6
]}

Lavandero, Sergio ^{[1
,2
,5
,6
]}

机构：

[1] Univ Chile, Fac Chem & Pharmaceut Sci, Adv Ctr Chron Dis ACCDiS, Santiago 8380492, Chile

[2] Univ Chile, Fac Med, Santiago 8380492, Chile

[3] Pontificia Univ Catolica Chile, Fac Med, Adv Ctr Chron Dis ACCDiS, Santiago, Chile

[4] Pontificia Univ Catolica Chile, Fac Med, Anesthesiol Div, Santiago, Chile

[5] Internal Med Div Cardiol, Dallas, TX USA

[6] Univ Texas SW Med Ctr Dallas, Mol Biol, Dallas, TX 75390 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2015年 / 1853卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Insulin signaling; Diabetic cardiomyopathy; Mitochondrial dynamics; MYOCARDIAL CONTRACTILE DYSFUNCTION; DIET-INDUCED OBESITY; CARDIAC MYOCYTES; HEART-FAILURE; CELL-DEATH; ADULT CARDIOMYOCYTES; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; O-GLCNACYLATION; FAILING HEART;

D O I：

10.1016/j.bbamcr.2015.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1113 / 1118

页数：6

共 85 条

[1] Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways [J].