Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats

被引：6

作者：

Coudore, F ^{[1
]}

Besson, A ^{[1
]}

Courteix, C ^{[1
]}

Eschalier, A ^{[1
]}

Lavarenne, J ^{[1
]}

Fialip, J ^{[1
]}

机构：

[1] NEUROPSYCHOPHARMACOL UNIV AUVERGNE,EQUIPE,FAC MED,LAB PHARMACOL MED,F-63001 CLERMONT FERRAN 1,FRANCE

来源：

GENERAL PHARMACOLOGY | 1996年 / 27卷 / 05期

关键词：

amitriptyline; demethylated and hydroxylated metabolites; diabetic; rat; kinetics;

D O I：

10.1016/0306-3623(95)02082-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Plasma and brain levels of amitriptyline (AMI), its demethylated and hydroxylated metabolites were determined after acute IP administration of AMI (20 mg/kg) in streptozocin-induced diabetic Sprague-Dawley rats. Results showed 1. in plasma: rapid AML absorption, but slow elimination; the proportion of AMI similar to those of the rest of compounds; the proportion of its demethylated metabolite, nortriptyline, 1.8-fold higher than that of 10-hydroxy-nortriptyline. 2. in brain: the proportions of AMI and nortriptyline were 9.5- and 2.6-fold higher respectively, than those of whole hydroxylated metabolites, which represented 7.4% of the total amount.

引用

收藏

页码：803 / 807

页数：5

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