CRH in chronic inflammatory stress

被引：32

作者：

Jessop, DS ^{[1
]}

Harbuz, MS ^{[1
]}

Lightman, SL ^{[1
]}

机构：

[1] Univ Bristol, Res Ctr Neuroendocrinol, Bristol BS2 8HW, Avon, England

来源：

PEPTIDES | 2001年 / 22卷 / 05期

关键词：

CRH; inflammation; stress; substance P;

D O I：

10.1016/S0196-9781(01)00394-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Corticotropin-releasing hormone (CRH is an important regulator of inflammation at the central level through hypothalamo-pituitary-adrenal (HPA) axis control of glucocorticoid secretion. Integrity of the HPA axis during autoimmune disease is critical in controlling the severity of inflammation, but the evidence for an HPA axis defect in the etiology of autoimmune diseases is not compelling. CRH secreted from leukocytes and neuronal terminals in peripheral tissues also plays a role in mediating inflammation. Elucidating the pathways underlying the expression of CRH, both central and peripheral, and interactions of CRH with other inflammatory mediators such as: substance P, confers great potential for the development of a new generation of anti-inflammatory agents. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：803 / 807

页数：5

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