Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

被引：449

作者：

Capecchi, MR ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Human Genet, Howard Hughes Med Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 06期

关键词：

D O I：

10.1038/nrg1619

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene targeting in mouse embryonic stem cells has become the 'gold standard' for determining gene function in mammals. Since its inception, this technology has revolutionized the study of mammalian biology and human medicine. Here I provide a personal account of the work that led to the generation of gene targeting which now lies at the Centre of functional genomic analysis.

引用

页码：507 / 512

页数：6

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