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Lipoprotein lipase: Physiology, biochemistry, and molecular biology

被引：146
作者：
Goldberg, IJ
Merkel, M
机构：
[1] Columbia Univ Coll Phys & Surg, Div Prevent Med & Nutr, New York, NY 10032 USA
[2] Univ Hamburg, Hosp Eppendorf, Dept Internal Med, D-20246 Hamburg, Germany
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2001年 / 6卷
关键词：
triglyceride; chylomicrons; heparin; proteoglycans; hyperlpidemai; review;
D O I：
10.2741/Goldberg
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.
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页码：D388 / D405
页数：18
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