Lipoprotein lipase: Physiology, biochemistry, and molecular biology

被引：146

作者：

Goldberg, IJ

Merkel, M

机构：

[1] Columbia Univ Coll Phys & Surg, Div Prevent Med & Nutr, New York, NY 10032 USA

[2] Univ Hamburg, Hosp Eppendorf, Dept Internal Med, D-20246 Hamburg, Germany

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2001年 / 6卷

关键词：

triglyceride; chylomicrons; heparin; proteoglycans; hyperlpidemai; review;

D O I：

10.2741/Goldberg

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.

引用

页码：D388 / D405

页数：18

共 201 条

[61] HATA A, 1992, J BIOL CHEM, V267, P20132
[62] HATA A, 1990, AM J HUM GENET, V47, P721
[63] A NOVEL MISSENSE MUTATION IN THE GENE FOR LIPOPROTEIN-LIPASE RESULTING IN A HIGHLY CONSERVATIVE AMINO-ACID SUBSTITUTION (ASP(180) -] GLU) CAUSES FAMILIAL CHYLOMICRONEMIA (TYPE-I HYPERLIPOPROTEINEMIA)
HAUBENWALLNER, S
HORL, G
SHACHTER, NS
PRESTA, E
FRIED, SK
HOFLER, G
KOSTNER, GM
BRESLOW, JL
ZECHNER, R
[J]. GENOMICS, 1993, 18 (02) : 392 - 396
[64] PHENOTYPIC VARIATION OF MUTATIONS IN THE HUMAN LIPOPROTEIN-LIPASE GENE
HAYDEN, MR
KASTELEIN, JJ
FUNKE, H
BRUNZELL, JD
MA, YH
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (02) : 506 - 509
[65] A novel Glu421Lys substitution in the lipoprotein lipase gene in pregnancy-induced hypertriglyceridemic pancreatitis
Henderson, H
Leisegang, F
Hassan, F
Hayden, M
Marais, D
[J]. CLINICA CHIMICA ACTA, 1998, 269 (01) : 1 - 12
[66] Henderson HE, 1999, J LIPID RES, V40, P735
[67] THE LIPOPROTEIN-LIPASE GLY188-]GLU MUTATION IN SOUTH AFRICANS OF INDIAN DESCENT - EVIDENCE SUGGESTING COMMON ORIGINS AND AN INCREASED FREQUENCY
HENDERSON, HE
HASSAN, F
BERGER, GMB
HAYDEN, MR
[J]. JOURNAL OF MEDICAL GENETICS, 1992, 29 (02) : 119 - 122
[68] Henderson HE, 1998, AM J MED GENET, V78, P313, DOI 10.1002/(SICI)1096-8628(19980724)78:4<313::AID-AJMG1>3.0.CO
[69] 2-M
[70] HENDERSON HE, 1990, MOL BIOL MED, V7, P511

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