Asymmetric catalytic hydrogenation in CO2 expanded methanol -: an application of gas anti-solvent reactions (GASR)

被引：24

作者：

Combes, GB ^{[1
]}

Dehghani, F ^{[1
]}

Lucien, FP ^{[1
]}

Dillow, AK ^{[1
]}

Foster, NR ^{[1
]}

机构：

[1] Univ New S Wales, Sch Chem Engn & Ind Chem, Sydney, NSW 2052, Australia

来源：

REACTION ENGINEERING FOR POLLUTION PREVENTION | 2000年

关键词：

D O I：

10.1016/B978-044450215-5/50086-X

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The technical feasibility of performing reactions in a novel solvent medium was investigated. The reaction considered was the asymmetric hydrogenation of 2-(6'methoxy-2'-naphthyl) acrylic acid to (S)-Naproxen using a [(S)-Ru(BINAP)Cl]Cl p-cymene catalyst. The reaction was performed in methanol at 298 K, and in methanol expanded with carbon dioxide at both 288 K and 298 K. Preliminary results showed that the reaction rate was significantly faster in expanded methanol than in pure methanol at the same temperature. The increase in rate is probably due in part to the higher hydrogen solubility attainable in the expanded liquid phase compared with pure methanol.

引用

页码：173 / 181

页数：9

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