Contribution of the Epstein-Barr virus to the molecular pathogenesis of Hodgkin lymphoma

被引：72

作者：

Kapatai, G.

Murray, P. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Pathol, Div Canc Studies, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Med, Canc Res UK Inst Canc Studies, Birmingham, W Midlands, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2007年 / 60卷 / 12期

关键词：

D O I：

10.1136/jcp.2007.050146

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Although the morphology of the pathognomonic Reed Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of HL in some cases. This review summarises current knowledge of the pathogenesis of HL with particular emphasis on the association with EBV.

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页码：1342 / 1349

页数：8

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