Tropomyosin isoforms: divining rods for actin cytoskeleton function

被引：241

作者：

Gunning, PW

Schevzov, G

Kee, AJ

Hardeman, EC

机构：

[1] Childrens Hosp, Oncol Res Unit, Westmead, NSW 2145, Australia

[2] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia

[3] Childrens Med Res Inst, Muscle Dev Unit, Westmead, NSW 2145, Australia

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.tcb.2005.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Actin filament functional diversity is paralleled by variation in the composition of isoforms of tropomyosin in these filaments. Although the role of tropomyosin is well understood in skeletal muscle, where it regulates the actin-myosin interaction, its role in the cytoskeleton has been obscure. The intracellular sorting of tropomyosin isoforms indicated a role in spatial specialization of actin filament function. Genetic manipulation and protein chemistry studies have confirmed that these isoforms are functionally distinct. Tropomyosins differ in their recruitment of myosin motors and their interaction with actin filament regulators such as ADF-cofilin. Tropomyosin isoforms have therefore provided a powerful mechanism to diversify actin filament function in different intracellular compartments.

引用

页码：333 / 341

页数：9

共 99 条

[71]

2-C

[72] Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex [J].