Single amino acid analogs of a myasthenogenic peptide modulate specific T cell responses and prevent the induction of experimental autoimmune myasthenia gravis

被引：18

作者：

Katz-Levy, Y

Dayan, M

Wirguin, I

Fridkin, M

Sela, M

Mozes, E ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel

[3] Ben Gurion Univ Negev, Fac Hlth Sci, Soroka Med Ctr, Dept Neurol, Beer Sheva, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 85卷 / 01期

关键词：

altered peptide ligands; acetylcholine receptor; myasthenia gravis; T cell inhibition;

D O I：

10.1016/S0165-5728(97)00265-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peptide p259-271 of the human acetylcholine receptor alpha-subunit, preferentially stimulates T cells of patients with myasthenia gravis (MG) and is an immunodominant epitope for T cells of BALB/c mice. A p259-271 specific T cell line of BALB/c origin was established and was shown to induce experimental MG in naive mice. Seven analogs of p259-271 were synthesized, and two of them were found to inhibit the p259-271 specific proliferative responses of the line and of p259-271 primed lymph node cells, Moreover, the most efficient inhibitor, analog 262Lys, prevented the MG related manifestations in mice inoculated with the line, and might be of potential value for the treatment of MG. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：78 / 86

页数：9

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[21] ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS [J].