Cellular redox: A modulator of intestinal epithelial cell proliferation

被引：95

作者：

Aw, TY ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Mol & Cellular Physiol, Shreveport, LA 71130 USA

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01448.2003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mucosal proliferation, together with differentiation and apoptosis, are a continuous homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox status plays a key role in intestinal growth control wherein a reduced redox potential maintains a proliferative state. An oxidative shift in this potential elicits growth arrest and cell transition to a differentiated or apoptotic phenotype.

引用

页码：201 / 204

页数：4

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