β-amyloid:: friend or foe

被引:15
作者
Campbell, A [1 ]
机构
[1] Univ Calif Irvine, Dept Community & Environm Med, Irvine, CA 92697 USA
关键词
D O I
10.1054/mehy.2000.1212
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The function of the amyloid precursor protein (APP) and its product, beta -amyloid, (A beta) is at present unknown. The deposition of AP in senile plaques as well as meningeal and cerebral vessels has led many researchers to discount the possibility of a beneficial protective function for the protein. Thus it is generally believed that the aberrant processing of APP leads to increased beta -amyloid secretion that in turn leads to subsequent plaque formation and Alzheimer's disease. Here, a hypothesis is presented that the protein may indeed be protective and that a potential role for beta amyloid in innate immunity may exist. (C) 2001 Harcourt Publishers Ltd.
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收藏
页码:388 / 391
页数:4
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