Glial reaction in the hippocampal formation is highly correlated with aging in human brain

被引:112
作者
David, JP
Ghozali, F
FalletBianco, C
Wattez, A
Delaine, S
Boniface, B
DiMenza, C
Delacourte, A
机构
[1] FAC PHARM,LAB BIOMATH,F-59006 LILLE,FRANCE
[2] HOP EMILE ROUX,SERV GERONTOL CLIN,F-94456 LIMEIL BREVANNES,FRANCE
[3] INSERM U422,F-59045 LILLE,FRANCE
基金
美国国家卫生研究院;
关键词
glial fibrillary acidic protein; aging; astrocytes; hippocampus;
D O I
10.1016/S0304-3940(97)00708-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glial fibrillary acidic protein (GFAP), a biochemical marker of astrocytes and glial reaction, was quantified by immunoblotting in different brain areas from 33 non-demented patients with a Mini Mental State Examination score above 26 and aged from 12 to 98 years. An increase of GFAP with age was first found in the hippocampus and then in the entorhinal cortex. In both regions, GFAP amounts were correlated with age (r = 0.768). In the isocortex, the increase of GFAP as a function of age was also significant (r = 0.672), but less than for the hippocampal region. GFAP levels increased dramatically after the age of 65 years, and more especially in the hippocampal formation. This glial reaction was observed in aged controls that do not show cognitive impairment and the neuropathological hallmarks of Alzheimer's disease. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:53 / 56
页数:4
相关论文
共 17 条
[1]   NEUROFIBRILLARY TANGLE DENSITIES IN THE HIPPOCAMPAL-FORMATION IN A NONDEMENTED POPULATION DEFINE SUBGROUPS OF PATIENTS WITH DIFFERENTIAL EARLY PATHOLOGICAL-CHANGES [J].
BOURAS, C ;
HOF, PR ;
MORRISON, JH .
NEUROSCIENCE LETTERS, 1993, 153 (02) :131-135
[2]  
Brodmann K, 1909, VERGLEICHENDE LOKALI
[3]   AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease [J].
BueeScherrer, V ;
Condamines, O ;
MourtonGilles, C ;
Jakes, R ;
Goedert, M ;
Pau, B ;
Delacourte, A .
MOLECULAR BRAIN RESEARCH, 1996, 39 (1-2) :79-88
[4]   GENERAL AND DRAMATIC GLIAL REACTION IN ALZHEIMER BRAINS [J].
DELACOURTE, A .
NEUROLOGY, 1990, 40 (01) :33-37
[5]   ACIDIC PROTEIN ISOLATED FROM FIBROUS ASTROCYTES [J].
ENG, LF ;
VANDENHA.JJ ;
BIGNAMI, A ;
GERSTL, B .
BRAIN RESEARCH, 1971, 28 (02) :351-&
[6]   CORRELATION BETWEEN MICROSCOPICAL CHANGES AND TAU-64 AND TAU-69 BIOCHEMICAL DETECTION IN SENILE DEMENTIA OF THE ALZHEIMER TYPE - TAU-64 AND TAU-69 ARE RELIABLE MARKERS OF THE NEUROFIBRILLARY DEGENERATION [J].
FLAMENT, S ;
DELACOURTE, A ;
DELAERE, P ;
DUYCKAERTS, C ;
HAUW, JJ .
ACTA NEUROPATHOLOGICA, 1990, 80 (02) :212-215
[7]  
FOLSTEIN MF, 1984, ASSESSMENT GERIATRIC, P47
[8]   ASTROGLIA IN ALZHEIMERS-DISEASE [J].
FREDERICKSON, RCA .
NEUROBIOLOGY OF AGING, 1992, 13 (02) :239-253
[9]   AN IMMUNOHISTOCHEMICAL QUANTIFICATION OF FIBROUS ASTROCYTES IN THE AGING HUMAN CEREBRAL-CORTEX [J].
HANSEN, LA ;
ARMSTRONG, DM ;
TERRY, RD .
NEUROBIOLOGY OF AGING, 1987, 8 (01) :1-6
[10]   INCREASES OF GLIAL FIBRILLARY ACIDIC PROTEIN IN THE AGING FEMALE MOUSE-BRAIN [J].
KOHAMA, SG ;
GOSS, JR ;
FINCH, CE ;
MCNEILL, TH .
NEUROBIOLOGY OF AGING, 1995, 16 (01) :59-67