Interference between PARPs and SIRT1: a novel approach to healthy ageing?

被引：41

作者：

Canto, Carles ^{[1
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland

来源：

AGING-US | 2011年 / 3卷 / 05期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

aging; metabolism; longevity; sirtuins; PARP; POLY(ADP-RIBOSE) POLYMERASE-ACTIVITY; DNA-DAMAGE; LIFE-SPAN; NICOTINAMIDE; MICE; METABOLISM; MOUSE; INHIBITION; ACTIVATION; STABILITY;

D O I：

10.18632/aging.100326

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.

引用

页码：543 / 547

页数：5

共 32 条

[1]

Allinson SL, 2003, ACTA BIOCHIM POL, V50, P169

[2] PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase [J].

Amé, JC ;

Rolli, V ;

Schreiber, V ;

Niedergang, C ;

Apiou, F ;

Decker, P ;

Muller, S ;

Hoger, T ;

Murcia, JMD ;

de Murcia, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :17860-17868

[3] PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure [J].

Bai, Peter ;

Canto, Carles ;

Brunyanszki, Attila ;

Huber, Aline ;

Szanto, Magdolna ;

Cen, Yana ;

Yamamoto, Hiroyasu ;

Houten, Sander M. ;

Kiss, Borbala ;

Oudart, Hugues ;

Gergely, Pal ;

Menissier-de Murcia, Josiane ;

Schreiber, Valerie ;

Sauve, Anthony A. ;

Auwerx, Johan .

CELL METABOLISM, 2011, 13 (04) :450-460

[4] PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation [J].

Bai, Peter ;

Canto, Caries ;

Oudart, Hugues ;

Brunyanszki, Attila ;

Cen, Yana ;

Thomas, Charles ;

Yamamoto, Hiroyasu ;

Huber, Aline ;

Kiss, Borbala ;

Houtkooper, Riekelt H. ;

Schoonjans, Kristina ;

Schreiber, Valerie ;

Sauve, Anthony A. ;

Menissier-de Murcia, Josiane ;

Auwerx, Johan .

CELL METABOLISM, 2011, 13 (04) :461-468

[5] Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome [J].

Biddinger, SB ;

Almind, K ;

Miyazaki, M ;

Kokkotou, E ;

Ntambi, JM ;

Kahn, CR .

DIABETES, 2005, 54 (05) :1314-1323

[6] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1 [J].

Bitterman, KJ ;

Anderson, RM ;

Cohen, HY ;

Latorre-Esteves, M ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45099-45107

[7] Caloric restriction, SIRT1 and longevity [J].

Canto, Caries ;

Auwerx, Johan .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2009, 20 (07) :325-331

[8] NICOTINAMIDE MONONUCLEOTIDE ACTIVATION OF A NEW DNA-DEPENDENT POLYADENYLIC ACID SYNTHESIZING NUCLEAR ENZYME [J].

CHAMBON, P ;

MANDEL, P ;

WEILL, JD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1963, 11 (01) :39-&

[9] Genetic background determines metabolic phenotypes in the mouse [J].

Champy, Marie-France ;

Selloum, Mohammed ;

Zeitler, Valirie ;

Caradec, Claudia ;

Jung, Barbara ;

Rousseau, Stephane ;

Pouilly, Laurent ;

Sorg, Tania ;

Auwerx, Johan .

MAMMALIAN GENOME, 2008, 19 (05) :318-331

[10] Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse [J].

de Murcia, JMN ;

Ricoul, M ;

Tartier, L ;

Niedergang, C ;

Huber, A ;

Dantzer, F ;

Schreiber, V ;

Amé, JC ;

Dierich, A ;

LeMeur, M ;

Sabatier, L ;

Chambon, P ;

de Murcia, G .

EMBO JOURNAL, 2003, 22 (09) :2255-2263

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