Hypertrophic pulmonary osteoarthropathy (Marie-Bamberger syndrome) with clubbed fingers and arthralgia, a reversible paraneoplastic syndrome in non-small-cell bronchial carcinoma

被引:9
作者
Fietz, T
Schneider, P
Knauf, WU
Thiel, E
机构
[1] Free Univ Berlin, Klinikum Benjamin Franklin, Med Klin 3, D-12200 Berlin, Germany
[2] Free Univ Berlin, Klinikum Benjamin Franklin, Chirurg Klin & Poliklin, Abt Allgemein Gefass & Thoraxchirurg, D-12200 Berlin, Germany
关键词
D O I
10.1055/s-2007-1024216
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
History and clinical findings: During chemotherapy for a nonsmall-cell bronchial carcinoma with metastasis to the right femur (previously locally excised), a 34-year-old man suddenly developed severe, lasting joint pain in the ankle, knee, elbow and wrist without signs of increased warmth or swelling of these joints. At the time of diagnosis clubbed fingers had been noted. Investigations: Radiography of the hands showed bilateral periosteal hyperostoses. Computed tomography of the thorax revealed tumor progression. Diagnosis, treatment and course: The triad of clubbed fingers, periosteal hyperostoses and arthralgia/arthritis with the pulmonary findings established the diagnosis of hypertrophic pulmonary osteoarthritis (HPO; Marie-Bamberger syndrome). Initially there had merely been the signs of the much more frequent incomplete form with only the clubbed fingers, the complete form developing with progression of the disease during chemotherapy, joint pains dominating the symptoms. After right upper lobectomy (primary adenocarcinoma) the joint pains ceased and the finger clubbing regressed. Conclusions: Only 10% of non-small-cell bronchial carcinomas are associated with HPO. Conversely, such a tumor is found in 90% of HPO of recent onset and should therefore be sought of when searching for the primary tumor. The signs of HPO are reversible if the underlying disease is adequately treated.
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页码:1507 / 1511
页数:5
相关论文
共 10 条
[1]  
BAMBERGER E, 1891, Z KLIN MED, V18, P193
[2]  
DICKINSON CJ, 1987, LANCET, V2, P1434
[3]   THE ETIOLOGY OF CLUBBING AND HYPERTROPHIC OSTEOARTHROPATHY [J].
DICKINSON, CJ .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1993, 23 (06) :330-338
[4]   ASSOCIATION BETWEEN PLATELET MICROTHROMBI AND FINGER CLUBBING [J].
FOX, SB ;
DAY, CA ;
GATTER, KC .
LANCET, 1991, 338 (8762) :313-314
[5]   PACHYDERMOPERIOSTOSIS [J].
JANSEN, T ;
BRANDL, G ;
BANDMANN, M ;
MEUER, M .
HAUTARZT, 1995, 46 (06) :429-435
[6]   Treatment of resistant pain in hypertrophic pulmonary osteoarthropathy with subcutaneous octreotide [J].
Johnson, SA ;
Spiller, PA ;
Faull, CM .
THORAX, 1997, 52 (03) :298-299
[7]  
Marie P., 1890, REV MED, V10, P1
[8]  
MARTINEZLAVIN M, 1993, J RHEUMATOL, V20, P1386
[9]   Commentary: Octreotide and hypertrophic pulmonary osteoarthropathy [J].
Penson, RT ;
Rudd, RM .
THORAX, 1997, 52 (03) :297-298
[10]   Hypertrophic osteoarthropathy: Endothelium and platelet function [J].
Silveri, F ;
DeAngelis, R ;
Argentati, F ;
Brecciaroli, D ;
Muti, S ;
Cervini, C .
CLINICAL RHEUMATOLOGY, 1996, 15 (05) :435-439