Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil

被引：66

作者：

Kossuga, Miriam H. ^{[1
]}

Nascimento, Andea M. ^{[1
]}

Reimao, Juliana Q. ^{[2
]}

Tempone, Andre G. ^{[2
]}

Taniwaki, Noemi Nosomj ^{[3
]}

Veloso, Katyuscya ^{[4
]}

Ferreira, Antonio G. ^{[4
]}

Cavalcanti, Bruno C. ^{[5
]}

Pessoa, Claudia ^{[5
]}

Moraes, Manoel O. ^{[5
]}

Mayer, Alejandro M. S. ^{[6
]}

Hajdu, Eduardo ^{[7
]}

Berlinck, Roberto G. S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, BR-13560970 Sao Carlos, SP, Brazil

[2] Adolfo Lutz Inst, Dept Parasitol, Lab Toxinol Aplicada, BR-01246000 Sao Paulo, Brazil

[3] Adolfo Lutz Inst, Secao Microscopia Eletron, BR-01246000 Sao Paulo, Brazil

[4] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP, Brazil

[5] Univ Fed Ceara, Expt Oncol Lab, Fortaleza, Ceara, Brazil

[6] Midwestern Univ, Chicago Coll Psteopath Med, Dept Pharmacol, Downers Grove, IL 60515 USA

[7] Univ Fed Rio de Janeiro, Museu Nacl, BR-20940040 Rio De Janeiro, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 03期

关键词：

D O I：

10.1021/np0705256

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone (1) as a new polyketide, along with five known polyketides (2-6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P (3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2-6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.

引用

页码：334 / 339

页数：6

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