Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial

被引：31

作者：

Biemann, Ronald ^{[1
]}

Penner, Marina ^{[1
]}

Borucki, Katrin ^{[1
]}

Westphal, Sabine ^{[1
]}

Luley, Claus ^{[1
]}

Roenicke, Raik ^{[1
]}

Biemann, Kathleen ^{[1
]}

Weikert, Cornelia ^{[2
,3
]}

Lux, Anke ^{[4
]}

Goncharenko, Nikolai ^{[5
]}

Marschall, Hanns-Ulrich ^{[6
]}

Schneider, Jochen G. ^{[7
,8
]}

Isermann, Berend ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Inst Clin Chem & Pathobiochem, Magdeburg, Germany

[2] Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany

[3] Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[4] Otto Von Guericke Univ, Inst Biometr & Med Informat, Magdeburg, Germany

[5] IBBL Integrated BioBank Luxembourg, Luxembourg, Luxembourg

[6] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden

[7] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Luxembourg, Luxembourg

[8] Saarland Univ Med Ctr Homburg Saar, Dept Internal Med 2, Homburg, Germany

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

GLUCAGON-LIKE PEPTIDE-1; Y GASTRIC BYPASS; GROWTH-FACTOR; 19; METABOLIC SYNDROME; INSULIN SENSITIVITY; GLUCOSE; SURGERY; EXPRESSION; INCREASES; RECEPTOR;

D O I：

10.1038/srep30173

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). 74 non-smoking men (45-55 yr) with MetS were randomised to a lifestyle-induced weight loss program (supervision via telemonitoring) or to a control arm. Before and after a 6 months intervention period clinical and laboratory parameters, body composition, serum BA profile, FGF-19, and GLP-1 concentrations were determined in fasting blood samples. 30 participants in the control and 33 participants in the treatment arm completed the study and were included in the data analysis. In participants of the treatment arm lifestyle-induced weight loss resulted in markedly improved insulin sensitivity. Serum levels of BA species and total GLP-1 decreased, while FGF-19 remained stable. Serum BA composition changed towards an increased 12 alpha-hydroxylated/non-12 alpha-hydroxylated ratio. None of these parameters changed in participants of the control arm. Our results demonstrate that improved metabolic control by lifestyle modifications lowers serum levels of BAs and GLP-1 and changes serum BA composition towards an increased 12 alpha/non-12 alpha ratio (ICTRP Trial Number: U1111-1158-3672).

引用

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