Staurosporine and ent-staurosporine: The first total syntheses, prospects for a regioselective approach, and activity profiles

被引：123

作者：

Link, JT

Raghavan, S

Gallant, M

Danishefsky, SJ

Chou, TC

Ballas, LM

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

[2] MEM SLOAN KETTERING CANC CTR,BIOORGAN CHEM LAB,SLOAN KETTERING INST CANC RES,NEW YORK,NY 10021

[3] MEM SLOAN KETTERING CANC CTR,PROGRAM MOLEC PHARMACOL,SLOAN KETTERING INST CANC RES,NEW YORK,NY 10021

[4] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

[5] ELI LILLY & CO,SPHINX PHARMACEUT,DURHAM,NC 27707

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 12期

关键词：

D O I：

10.1021/ja952907g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo-glycal by direct epoxidation. The second bond was assembled from an exo-glycal by intramolecular iodoglycosylation.

引用

页码：2825 / 2842

页数：18

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