S-adenosylmethionine and its products

被引：123

作者：

Grillo, M. A. ^{[1
]}

Colombatto, S. ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Med & Oncol Sperimentale Biochim, Turin, Italy

来源：

AMINO ACIDS | 2008年 / 34卷 / 02期

关键词：

homocysteine; methylthioadenosine; 5-deoxyadenosine;

D O I：

10.1007/s00726-007-0500-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.

引用

页码：187 / 193

页数：7

共 69 条

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