S-adenosylmethionine and its products

被引:123
作者
Grillo, M. A. [1 ]
Colombatto, S. [1 ]
机构
[1] Univ Turin, Dipartimento Med & Oncol Sperimentale Biochim, Turin, Italy
关键词
homocysteine; methylthioadenosine; 5-deoxyadenosine;
D O I
10.1007/s00726-007-0500-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.
引用
收藏
页码:187 / 193
页数:7
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