Enteric pathogens and gut function: Role of cytokines and STATs

被引：45

作者：

Shea-Donohue, Terez ^{[1
,3
]}

Fasano, Alessio ^{[2
,3
]}

Smith, Allen ^{[4
]}

Zhao, Aiping ^{[1
,3
]}

机构：

[1] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Baltimore, MD 21201 USA

[4] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA

来源：

GUT MICROBES | 2010年 / 1卷 / 05期

关键词：

cytokine; STAT4; STAT6; epithelial cell; smooth muscle; mucosal permeability. A/E pathogens; enteric nematodes;

D O I：

10.4161/gmic.1.5.13329

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The gut harbors the largest immune system in the body. The mucosa is considered to be the initial site of interaction with commensal and pathogenic organisms; therefore, it is the first line of defense against the pathogens. In response to the invasion of various pathogens, naive CD4(+) cells differentiate into subsets of T helper (Th) cells that are characterized by different cytokine profiles. Cytokines bind to cell surface receptors on both immune and non-immune cells leading to activation of JAK-STAT signaling pathway and influence gut function by upregulating the expression of specific target genes. This review considers the roles of cytokines and receptor-mediated activation of STATs on pathogen-induced changes in gut function. The focus on STAT4 and STAT6 is because of their requirement for the full development of Th1 and Th2 cytokine profiles.

引用

页码：316 / 324

页数：9

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