Malaria vector control in the third millennium: progress and perspectives of molecular approaches

被引：29

作者：

Catteruccia, Flaminia ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England

来源：

PEST MANAGEMENT SCIENCE | 2007年 / 63卷 / 07期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

malaria; Anopheles; Plasmodium; vector control; genomics;

D O I：

10.1002/ps.1324

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Remarkable progress has been made towards a deeper understanding of mosquito biology since the completion of the Anopheles gambiae Giles genome project. Combined with the development of efficient transgenic technologies for genetic modification of major vector species and the availability of powerful molecular, genetic and bioinformatics tools, this is allowing the identification of genes involved in mosquito biological functions crucial to malaria transmission, ranging from host-seeking behaviour and innate immunity to insecticide resistance. Moreover, population genetic studies are beginning to elucidate the complex structure of vector populations. Finally, novel methods for malaria control are emerging that are based on the use of genetically modified mosquitoes either to interrupt the journey of the Plasmodium parasite within its insect host or to suppress those mosquito species that function as vectors for parasite transmission. (c) 2007 Society of Chemical Industry.

引用

页码：634 / 640

页数：7

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