Functional MRI studies of animal models in epilepsy

被引:24
作者
Blumenfeld, Hal
机构
[1] Yale Univ, Dept Neurol, New Haven, CT 06520 USA
[2] Yale Univ, Dept Neurobiol, New Haven, CT USA
[3] Yale Univ, Dept Neurosurg, New Haven, CT USA
[4] Yale Univ, Magnet Resonance Res Ctr, New Haven, CT USA
关键词
BOLD; seizure; CBF; neuroimaging; EEG; laser Doppler flowmetry;
D O I
10.1111/j.1528-1167.2007.01238.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Functional magnetic resonance imaging (fMRI) has become a widely used imaging modality in the past decade in both human studies and animal models. Epilepsy presents unique challenges for neuroimaging due to subject movement during seizures, and the need to correlate the timing of often unpredictable seizure events with fMRI data acquisition. These challenges can readily be overcome in animal models of epilepsy. Animal models also provide an opportunity to investigate the fundamental relationships between fMRI signals and brain electrical activity through invasive studies not possible in humans. fMRI studies in animal models of epilepsy can enable us to correctly interpret fMRI signal increases and decreases in human studies, ultimately elucidating specific networks that will be targeted for improved treatment of epilepsy.
引用
收藏
页码:18 / 26
页数:9
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