Bursting calcium rotors in cultured cardiac myocyte monolayers

被引：84

作者：

Bub, G

Glass, L

Publicover, NG

Shrier, A

机构：

[1] McGill Univ, Dept Physiol, Montreal, PQ H3G 1Y6, Canada

[2] Univ Nevada, Sch Med, Reno, NV 89557 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 17期

关键词：

D O I：

10.1073/pnas.95.17.10283

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rotating waves (rotors) of cellular activity were observed in nonconfluent cultures of embryonic chick heart cells by using a macroscopic imaging system that detected fluorescence from intracellular Ca2+. Unlike previous observations of rotors or spiral waves in other systems, the rotors did not persist but exhibited a repetitive pattern of spontaneous onset and offset leading to a bursting rhythm. Similar dynamics were observed in a cellular automaton model of excitable media that incorporates spontaneous initiation of activity, and a decrease of excitability as a consequence of rapid activity (fatigue). These results provide a mechanism for bursting dynamics in normal and pathological biological processes.

引用

页码：10283 / 10287

页数：5

共 33 条

[1] CIRCUS MOVEMENT IN RABBIT ATRIAL MUSCLE AS A MECHANISM OF TACHYCARDIA .2. ROLE OF NONUNIFORM RECOVERY OF EXCITABILITY IN OCCURRENCE OF UNIDIRECTIONAL BLOCK, AS STUDIED WITH MULTIPLE MICROELECTRODES [J].