Adenovirus-based genetic vaccines for biodefense

被引：41

作者：

Boyer, JL

Kobinger, G

Wilson, JM

Crystal, RG

机构：

[1] Cornell Univ, Weill Coll Med, Dept Med Genet, New York, NY 10021 USA

[2] Univ Penn, Dept Med, Div Med Genet, Gene Therapy Program, Philadelphia, PA 19104 USA

来源：

HUMAN GENE THERAPY | 2005年 / 16卷 / 02期

关键词：

D O I：

10.1089/hum.2005.16.157

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The robust host responses elicited against transgenes encoded by E1(-) E3(-) adenovirus ( Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

引用

页码：157 / 168

页数：12

共 88 条

[1]

[Anonymous], 2002, GERMS BIOL WEAPONS A

[2] Botulinum toxin as a biological weapon - Medical and public health management [J].

Arnon, SS ;

Schechter, R ;

Inglesby, TV ;

Henderson, DA ;

Bartlett, JG ;

Ascher, MS ;

Eitzen, E ;

Fine, AD ;

Hauer, J ;

Layton, M ;

Lillibridge, S ;

Osterholm, MT ;

O'Toole, T ;

Parker, G ;

Perl, TM ;

Russell, PK ;

Swerdlow, DL ;

Tonat, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (08) :1059-1070

[3] Bioterrorism: From threat to reality [J].

Atlas, RM .

ANNUAL REVIEW OF MICROBIOLOGY, 2002, 56 :167-185

[4] Bacillus anthracis, a bug with attitude! [J].

Baillie, L ;

Read, TD .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (01) :78-81

[5] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[6] Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 [J].

Bergelson, JM ;

Cunningham, JA ;

Droguett, G ;

KurtJones, EA ;

Krithivas, A ;

Hong, JS ;

Horwitz, MS ;

Crowell, RL ;

Finberg, RW .

SCIENCE, 1997, 275 (5304) :1320-1323

[7] Immune responses to gene therapy vectors: influence on vector function and effector mechanisms [J].

Bessis, N ;

GarciaCozar, FJ ;

Boissier, MC .

GENE THERAPY, 2004, 11 (Suppl 1) :S10-S17

[8] Hemorrhagic fever viruses as biological weapons - Medical and public health management [J].

Borio, L ;

Inglesby, T ;

Peters, CJ ;

Schmaljohn, AL ;

Hughes, JM ;

Jahrling, PB ;

Ksiazek, T ;

Johnson, KM ;

Meyerhoff, A ;

O'Toole, T ;

Ascher, MS ;

Bartlett, J ;

Breman, JG ;

Eitzen, EM ;

Hamburg, M ;

Hauer, J ;

Henderson, A ;

Johnson, RT ;

Kwik, G ;

Layton, M ;

Lillibridge, S ;

Nabel, GJ ;

Osterholm, MT ;

Perl, TM ;

Russell, P ;

Tonat, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (18) :2391-2405

[9]

Brachman P. S., 1999, VACCINES, P629

[10]

Chiuchiolo M, 2004, MOL THER, V9, pS215

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