Thalassemia: An Overview of 50 Years of Clinical Research

被引：54

作者：

Sankaran, Vijay G. ^{[1
,2
,3
,4
]}

Nathan, David G. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Childrens Hosp Boston, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 06期

关键词：

Thalassemia; Hemoglobin; Erythrocyte; Transfusion; FETAL-HEMOGLOBIN PRODUCTION; SICKLE-CELL-ANEMIA; GLOBIN GENE-EXPRESSION; MURINE BETA-THALASSEMIA; GENOME-WIDE ASSOCIATION; PRENATAL-DIAGNOSIS; ALPHA-THALASSEMIA; DNA POLYMORPHISMS; MESSENGER-RNA; IRON OVERLOAD;

D O I：

10.1016/j.hoc.2010.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The thalassemias are attributable to the defective production of the alpha- and beta-globin polypeptides of hemoglobin Significant discoveries have illuminated the pathophysiology and enhanced the prevention and treatment of the thalassemias and this article reviews many of the advances that have occurred in the past 50 years However the application of new approaches to the treatment of these disorders has been slow particularly in the developing world where the diseases are common but there is definite progress This article emphasizes how the increasing knowledge of cellular and molecular biology are facilitating the development of more effective therapies for these patients

引用

页码：1005 / +

页数：17

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