Commentary: Deciphering the link between architecture and biological response of a bone graft substitute

被引：113

作者：

Bohner, M. ^{[1
]}

Loosli, Y. ^{[1
]}

Baroud, G. ^{[2
]}

Lacroix, D. ^{[3
]}

机构：

[1] RMS Fdn, CH-2544 Bettlach, Switzerland

[2] Univ Sherbrooke, Lab Biomecan, Dept Genie Mecan, Sherbrooke, PQ J1K 2R1, Canada

[3] Inst Bioengn Catalonia, Barcelona 08028, Spain

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 02期

关键词：

Biomaterial; Bone; Tissue engineering; Resorbable; Graft; CALCIUM-PHOSPHATE SCAFFOLDS; MICRO-COMPUTED TOMOGRAPHY; TISSUE; DESIGN; QUANTIFICATION; CERAMICS; CELLS; MODEL; CT;

D O I：

10.1016/j.actbio.2010.08.008

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Hundreds of studies have been devoted to the search for the ideal architecture for bone scaffold. Despite these efforts, results are often contradictory, and rules derived from these studies are accordingly vague. In fact, there is enough evidence to postulate that ideal scaffold architecture does not exist. The aim of this document is to explain this statement and review new approaches to decipher the existing but complex link between scaffold architecture and in vivo response. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：478 / 484

页数：7

共 48 条

[1]

Theoretical model to determine the effects of geometrical factors on the resorption of calcium phosphate bone substitutes [J].