Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

被引：1484

作者：

Guilak, Farshid ^{[1
,2
]}

Cohen, Daniel M. ^{[4
]}

Estes, Bradley T. ^{[1
,2
]}

Gimble, Jeffrey M. ^{[5
]}

Liedtke, Wolfgang ^{[3
]}

Chen, Christopher S. ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Biomed Engn, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[4] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[5] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Stem Cell Lab, Baton Rouge, LA 70808 USA

来源：

CELL STEM CELL | 2009年 / 5卷 / 01期

关键词：

MESENCHYMAL PROGENITOR CELLS; MARROW STROMAL CELLS; CYCLIC STRAIN; CHONDROGENIC DIFFERENTIATION; CA2+ ENTRY; IN-VITRO; CHONDROCYTE DIFFERENTIATION; PHENOTYPIC TRAITS; TISSUE; SHAPE;

D O I：

10.1016/j.stem.2009.06.016

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

引用

页码：17 / 26

页数：10

共 126 条

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