Cytogenetic localization of cancer-related genes in the rat and comparative mapping studies in human and mouse

被引：11

作者：

Johansson, Å ^{[1
]}

Helou, K ^{[1
]}

Levan, G ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Cell & Mol Biol Genet, SE-40530 Gothenburg, Sweden

来源：

CYTOGENETICS AND CELL GENETICS | 1998年 / 81卷 / 3-4期

关键词：

D O I：

10.1159/000015034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The rat is an important model organism in biomedical research, and several well-characterized rat cancer model systems exist. To facilitate detailed analysis of these models, it is useful to know the regional location of known cancer-related genes. In this report, 14 cancer-related genes have been sublocalized by fluorescence in situ hybridization. The mapped genes include three oncogenes (Fyn, Mas1, and Vav1), a tyrosine kinase gene (Syk), a tumor-associated antigen gene (Cd24), a growth factor receptor gene (Igf2r), the gene for an activator of c-fos/c-jun transcription factors (Apex), a transcription factor gene (Egr3), and several genes involved in steroid hormone metabolism and signaling (Esr2, Pgr, Cbg, Cyp17, and Cyp19). The remaining gene (Map1a) is involved in microtubule assembly.

引用

页码：217 / 221

页数：5