Effect of infusion of vasoactive intestinal peptide (VIP)-antisense oligodeoxynucleotide into the third cerebral ventricle above the hypothalamic suprachiasmatic nucleus on the hyperglycemia caused by intracranial injection of 2-deoxy-D-glucose in rats

被引：7

作者：

Chun, SJ

Niijima, A

Shima, T

Okada, M

Nagai, K

机构：

[1] Osaka Univ, Inst Prot Res, Div Prot Metab, Suita, Osaka 5650871, Japan

[2] Niigata Univ, Sch Med, Niigata 9518122, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 257卷 / 03期

关键词：

glucose metabolism; glucagon; insulin; autonomic nervous system; central nervous system;

D O I：

10.1016/S0304-3940(98)00831-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effect of the infusion of a vasoactive intestinal peptide (VIP) antisense oligodeoxynucleotide into the third cerebral ventricle above the hypothalamic suprachiasmatic nucleus (SCN) using osmotic minipump for 3 days (0.2 nmol/ml per h) on the hyperglycemic response to intracerebroventricular injection of 2-deoxy-D-glucose (2DG) (80 mu mol) in rats. After the infusion of the VIP antisense the inhibition of VIP expression in the SCN was observed in association with suppressions of the hyperglycemia, hyperglucagonemia and relative hypoinsulinemia due to the 2DG injection. Furthermore, additional intracranial injection of VIP (4 nmol) restored these responses to the 2DG injection in rats treated with the VIP antisense. These findings suggest that VIP neurons in the SCN are involved in the regulation of glucose metabolism. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 138

页数：4

共 7 条

[1]

CHUN S, 1998, IN PRESS BRAIN RES

[2] THE COMPLETE STRUCTURE OF THE RAT VIP-GENE [J].